Dr. Halstead has to balance the stress as the ER’s supervising Attending Physician while exploring a budding romance with Dr. Manning. Dr. Rhodes – skills are put to the test with the arrival of a new, highly competitive Cardiothoracic Fellow. Dr. Charles recovers from both physical and psychological injuries and Dr. Reese continues her psychiatry residency despite new reservations. Dr. Ethan Choi brings his battlefield skills to the front lines of Chicago’s busiest ER. Sharon Goodwin balances the pressure of keeping the city’s largest hospital afloat while maintaining an atmosphere of quality care and compassion. April Sexton navigates the hospital politics of dating a doctor and co-worker.